The Magpies recorded their first victory in six matches when they beat Queens Park Rangers last weekend to move to 13th position.
Arsenal require just a point to all but assure a top-four position in the table.
However, boss Arsene Wenger will be eager to overtake Chelsea in third position to avoid having to take part in a qualifying match for the Champions League.
Newcastle United: DLDLDW
Possible starting lineups
Newcastle United: Harper; Coloccini, Williamson, Yanga-M'Biwa, Debuchy; Cabaye, Ben Arfa, Gutierrez, Perch; Cisse, Gouffran
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Rosicky, Wilshere, Walcott, Ramsey, Cazorla; Podolski
Sports Mole says: 1-2