Welbeck's old Manchester enemies are the visitors to the Emirates Stadium this weekend in a battle between two teams with genuine title ambitions.
Both sides are yet to convince this campaign, though, with Arsenal having relied on late goals to stay unbeaten and the Citizens having already slipped up.
City suffered a surprising 1-0 home defeat to Stoke City prior to the international break, but have not lost consecutive top-flight matches since 2010.
Heading into a week in which they also play Bayern Munich and Chelsea, Manuel Pellegrini has injury concerns over three regulars, with Stevan Jovetic back on the treatment table following a promising start to the season.
The Montenegro captain missed large chunks of last term due to fitness issues, but had given his City career new life with two goals in their first three games.
Sergio Aguero and Edin Dzeko are likely to play up front in his absence, while Fernandinho could reprise his midfield partnership with Yaya Toure after summer signing Fernando limped off against the Potters.
Bacary Sagna, who made 286 appearances during a seven-year spell with Arsenal, could play against the Gunners for the first time since he left them on a free transfer in May, with Pablo Zabaleta carrying a knock.
Big-money buy Eliaquim Mangala has been warned that he must fight for his place in the side, and the £32m defender may again have to settle for a place on a City bench which could include Frank Lampard for the first time.
Theo Walcott is still weeks away from returning to first-team contention, while Kieran Gibbs has been out of the team with injury and may find that Nacho Monreal has done enough to keep his place at left-back.
Arsenal are unbeaten in 19 Premier League home games and beat the Blues 3-0 in the Community Shield a month ago.
Man City: LWWL
Possible starting lineups
Arsenal: Szczesny; Debuchy, Koscielny, Mertesacker, Monreal; Arteta, Flamini; Cazorla, Ozil, Sanchez; Welbeck
Man City: Hart; Sagna, Demichelis, Kompany, Kolarov; Silva, Toure, Fernandinho, Nasri; Aguero, Dzeko
Sports Mole says: 1-2