The Gunners finally ended their longest winless run for 42 years by coming from behind to beat West Ham United on Monday night, but a midweek Europa League draw in Belgium means that they have now won just one of their last 11 outings across all competitions.
Arsenal also have a poor recent record against Man City, although the champions have been in inconsistent form themselves and Arsenal may be hopeful of getting a priceless victory for their ailing top-four hopes.
Here, Sports Mole looks at how interim boss Freddie Ljungberg could set his side up for the showdown.
Arsenal's main injury concern hangs over record signing Nicolas Pepe, who began to show signs of why the Gunners splashed so much money on him during their comeback against West Ham on Monday.
The winger was not able to build on that in midweek due to a bruised knee, but probably would have been rested anyway in the hope that he would be fully fit for the visit of the champions.
Ljungberg is set to give Pepe as much opportunity as possible to prove his fitness, and should he pass the late test then he is likely to start given Man City's troubles against pacy attacks in recent weeks.
Alexandre Lacazette had to watch on from the bench on Monday and may be forced to settle for the same role on Sunday despite scoring in midweek, with captain Pierre-Emerick Aubameyang set to lead the line.
Gabriel Martinelli is looking to become only the fourth Arsenal player to score on his first two Premier League starts for the club, with his strike against the Hammers putting him on course to equal the feat achieved by Ian Wright, Davor Suker and Alex Iwobi.
Matteo Guendouzi is expected to come back into the starting lineup with former skipper Granit Xhaka ruled out with concussion, while Sead Kolasinac is also set for a recall after Kieran Tierney suffered a dislocated shoulder which could keep him sidelined for up to three months.
There are also injury concerns on the other side of the defence with Hector Bellerin set for a late fitness test after pulling out of the West Ham match in the warm-up due to a tight hamstring.
David Luiz sat out the trip to the London Stadium and Calum Chambers will be hopeful of keeping his spot in defence, but the Brazilian's experience and knowledge of compatriot Gabriel Jesus could be enough for him to earn the nod.