However, Arteta is hopeful that both men will be able to line up here, leaving Granit Xhaka as the Gunners' only confirmed absentee as he battles his way back from a serious knee injury.
Arteta is unlikely to consider many changes from last week's 3-1 success over Aston Villa should his key figures be available, with Tierney's return potentially dropping Nuno Tavares down to the bench despite his eye-catching display on Friday.
Paying homage to the Invincibles on Arsene Wenger's birthday, Arteta opted for an old-school 4-4-2 setup against Villa and could do so again here, with Thomas Partey and Albert Sambi Lokonga pairing up in midfield.
Alexandre Lacazette's contributions against Crystal Palace and Villa have seen him force his way back into the first XI, while Pierre-Emerick Aubameyang will be out to score his first away goal of the league season this weekend.
Arsenal possible starting lineup: Ramsdale; Tomiyasu, White, Gabriel, Tierney; Saka, Partey, Lokonga, Smith Rowe; Aubameyang, Lacazette