Van Persie is expected to finalise his move today but Santos has insisted that bringing in players such as Santi Cazorla and Lukas Podolski will ensure that Arsenal have a successful season.
"We lost a lot. Van Persie is a high quality player, a big idol of the fans and he had a great [season last year], but I am sure the team is much more mature," ESPN quotes Santos as saying.
"Today we have experienced players and also the arrival of some new players, [such as] Santi Cazorla and Podolski, who are excellent.
"We are well focused, the team is well prepared and well motivated We have brought in some top quality players and I am sure that Arsenal will have a great campaign in the English league."
Santos scored two league goals in 15 appearances for the Gunners last season.