Conte makes nine changes in all from the Blues' goalless draw with Norwich City at the weekend, including returns for first-choice stopper Thibaut Courtois and former Gunners ace Cesc Fabregas in midfield.
Hazard will therefore start just off 12-goal striker Morata in an expected 3-5-2 formation, having shaken off a minor calf injury.
In terms of the visitors, who claimed a 2-2 draw when the teams faced off in the Premier League a week ago, boss Arsene Wenger has made a total of seven changes following his side's shock FA Cup exit at the hands of Nottingham Forest.
Ainsley Maitland-Niles, Rob Holding, Danny Welbeck and Alex Iwobi - the latter of whom has been embroiled in off-field controversy this week - keep their spots in the starting lineup for this London derby showdown.
CHELSEA: Courtois; Azpilicueta, Christensen, Rudiger; Moses, Kante, Fabregas, Drinkwater, Alonso; Hazard, Morata
Subs: Eduardo, David Luiz, Zappacosta, Bakayoko, Willian, Pedro, Batshuayi
ARSENAL: Ospina; Chambers, Mustafi, Holding; Wilshere, Xhaka; Bellerin, Maitland-Niles; Iwobi, Welbeck; Lacazette
Subs: Macey, Mavropanos, Mertesacker, Nelson, Elneny, Walcott, Sanchez
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