The Frenchman has used the competition to play his second string, and said that he will not divert from that strategy despite the calibre of opposition.
"I will rotate against Chelsea but play with a team that has a good chance to qualify as well," the 64-year-old told the club's official website.
"You worry about fatigue a little bit but not too much. Sometimes when you play every three days you look tired and then in three days you are flying again. It goes a bit in cycles."
The Gunners beat West Bromwich Albion on penalties in the third round.