Victory over Arsenal to make it seven wins in a row across all competitions would be the sweetest of the lot, though, with Spurs bidding to open up a six-point gap to their near neighbours.
Here, Sports Mole looks at how the visitors could line up at the Emirates.
Unlike their opponents, Spurs did not have the luxury of resting most of their senior players in midweek so many of the Champions League heroes are likely to start again this weekend, while match-winner Christian Eriksen will return to the XI.
Jan Vertonghen made his long-awaited return after six weeks out in that match, and Pochettino has little choice but to select him again at the Emirates with Davinson Sanchez sidelined and Juan Foyth still inexperienced at this level.
Danny Rose is also pushing for a return from injury having been named on the bench against Inter, but he may miss out to Ben Davies regardless whereas Kieran Trippier will be given every opportunity to prove that he has overcome a groin problem.