The Blues will hope to have Eden Hazard available from the off after easing the forward back into action following his World Cup exploits with Belgium.
Hazard, who has had mixed success in this fixture during his six years in English football, showed in 14 minutes on the field against Huddersfield Town last week he showed just why he is so highly rated.
Here, Sports Mole looks at how Hazard has fared against Arsenal in the past.
The 27-year-old has scored five goals against Arsenal since 2012, three of which have come in the last two seasons.
Hazard was on target in Chelsea's 2-1 EFL Cup semi-final defeat to the Gunners in January, temporarily putting his side into the lead before they crumbled at the Emirates Stadium.
That strike came three weeks after scoring from the penalty spot in a 2-2 Premier League draw, making it two in his last two against the North London outfit.
Hazard made no telling impact in Chelsea's FA Cup final loss in May 2017, however, and he has also fired blanks in eight of the 12 top-flight encounters.
One assist across the 16 fixtures in all competitions is not the best return for a player of such quality, either, with that coming in the 2015-16 home match when his shot flew in off Calum Chambers.