The Gunners are just two victories away from ending an eight-year trophy drought as they prepare to take on Wigan Athletic at Wembley in the semi-final on Saturday.
"It is the biggest cup in the world and a big tradition," Podolski told the club's official website. "The Premier League title is the best one in England but I think when you have a chance to win the FA Cup, you have to give 110% to win. We have the chance now and we have to fight for this."
In the league, Arsenal are currently fourth with five games left to play.