The French striker has been largely used as an impact player this term, but he has been given the nod to start this evening's potentially decisive Group A showdown in North London.
David Ospina, Kieran Gibbs and Alex Iwobi also return to the first-team fold from the 1-1 draw with Manchester United last time out, with Petr Cech, Nacho Monreal, Mohamed Elneny and Theo Walcott the men to miss out.
The visitors are without a number of key players, meanwhile, including former Man United wideman Angel Di Maria who failed a late fitness test on a thigh injury.
With Javier Pastore also absent, Blaise Matuidi will join Edinson Cavani and Lucas Moura in a front three, with PSG - and indeed Arsenal - knowing that three points this evening will seal top spot in the group.
Arsenal: Ospina, Jenkinson, Mustafi, Koscielny, Gibbs, Coquelin, Ramsey, Alexis, Ozil, Iwobi, Giroud
Subs: Cech, Monreal, Gabriel, Xhaka, Elneny, Oxlade-Chamberlain, Walcott
Paris Saint-Germain: Areola; Maxwell, T.Silva, Marquinhos, Meunier; Motta, Krychowiak, Verratti; Matuidi, Cavani, Lucas
Subs: Trapp, Kimpembe, Ben Arfa, Jese, Nkunku, Augustin, Ikone
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