Carlo Ancelotti's side have scored seven goals in their previous two fixtures, picking up comprehensive victories against Olympiakos and Benfica.
PSG are also flying domestically as they sit two points clear of Monaco at the top of the Ligue 1 table following an unbeaten start to the campaign.
Anderlecht start the game at the bottom of Group C thanks to two defeats from their first two outings.
Possible starting lineups
Anderlecht: Kaminski; Mbemba, Kouyate, Nuytinck, N'Sakala; Bruno, Praet, Milivojevic, Tielemans, Suarez; Mitrovic
PSG: Sirigu; Jallet, Alex, Marquinhos, Digne; Lucas, Rabiot, Matuidi, Ongenda; Ibrahimovic, Cavani
Sports Mole says: 0-3