Bologna vs. Lazio (Sunday, 11.30am)
Victory in both the Derby della Capitale and over Lokomotiv Moscow in the Europa League sets the Aquile up for a shot at their third straight win, while their hosts are without victory in three games.
We say: Bologna 1-2 Lazio
Neither side are stable enough defensively to sustain a prolonged period of form as things stand, which should make for an open encounter on Sunday afternoon.
Even after a midweek European fixture, though, Lazio should have enough gas in the tank to end Bologna's undefeated start at Dall'Ara, and keep themselves in touch with the top clubs near the Serie A summit.
Hellas Verona vs. Spezia (Sunday, 2.00pm)
Despite their recent improvement, Verona sit just three places above their 17th-placed opponents in the standings.
We say: Hellas Verona 1-1 Spezia
Despite suffering consecutive defeats, Spezia deserve plenty of respect ahead of this contest after performing at a high level against two of the division's giants. With that in mind, we are backing the visitors to claim a share of the spoils, adding a further point to their solid away record.
Sampdoria vs. Udinese (Sunday, 2.00pm)
The visitors sit in 13th position after three successive defeats, while their hosts are two places lower after succumbing twice in a row.
We say: Sampdoria 2-1 Udinese
Neither team will want another defeat on their record before the international break as they bid to remain clear of the relegation zone. With that in mind, do not be surprised to see a low-scoring draw play out at the Luigi Ferraris Stadium.
Fiorentina vs. Napoli (Sunday, 5.00pm)
The Partenopei may have swept aside all-comers in the opening weeks of the season, but their resurgent hosts are on a run of four wins from five and sit fifth in the standings.
We say: Fiorentina 1-1 Napoli
Fiorentina and Napoli have conceded the joint-fewest goals in the first half of Serie A matches ahead of this intriguing contest, with both clubs having let just one goal in before the interval in six games so far.
It could, therefore, be a tense affair despite either side's attacking abilities - with the visitors set to drop their first points of the campaign against much-improved opponents.
Roma vs. Empoli (Sunday, 5.00pm)
While the Giallorossi were able to bounce back from their loss to Lazio with a Europa Conference League win in midweek, they will be wary of their visitors, who have just posted successive victories and previously overturned Juventus.
We say: Roma 2-1 Empoli
Having shown signs of defensive fragility in the past couple of weeks, Roma are certainly vulnerable to the enterprising approach of an Empoli side full of confidence - and with nothing much to lose.
Therefore, Mourinho's men will have to battle for the three points, but can scrape home due to a potentially decisive array of options in the final third.
Atalanta vs. AC Milan (Sunday, 7.45pm)
The pair meet in a second successive Lombardy derby in Serie A, following La Dea's breathless draw with champions Inter last weekend, while Milan come into the game sitting second in the league after five wins from six so far.
We say: Atalanta BC 2-1 AC Milan
Having stuttered in Europe and been far from convincing in beating Spezia last weekend, Milan's unbeaten start could come to an end in Bergamo.
Atalanta have proved their mettle among the top clubs yet again, with an impressive display against the Rossoneri's rivals Inter indicating they are stirring into life - and despite injuries on the flanks, up front they boast several potent options.