The home side were 10 points up at the end of the first quarter, and continued to extend their lead until late on, with Brook Lopez leading the scoring with 27 points.
The Miami Heat recorded a second consecutive win to give themselves a winning record for the first time since the opening game of the season.
Jonas Valanciunas got the Toronto Raptors off to a strong start against the current NBA champions, scoring 10 points in the opening quarter, but LeBron James ensured that the score kept rising for the Heat, finishing the game with 35 points to lead Miami to a 104-95 win.
The road side had eight players on the scoreboard at the end of the first quarter, as they outscored the Lakers by 13 points in the opening 12 minutes, while Monta Ellis finished the game with 30 points.
Pau Gasol was the only Lakers player to reach double figures, scoring 10 points during a 32-minute spell.
The NBA's only unbeaten side looked to be in trouble, finding themselves three points behind at half time, but a Paul George-led spell in the third quarter helped Detroit open up a comfortable lead.
The Charlotte Bobcats survived a late comeback from the New York Knicks, securing a 102-97 win at Madison Square Garden.
The visitors had a 10-point advantage after the first two quarters, but Carmelo Anthony added 32 points as the Knicks looked for their second win of the season.
However, 25 points, five rebounds, six assists and a steal from Kemba Walker was enough for the Bobcats to hold on.
The teams were close throughout, with Dwight Howard scoring 28 for the hosts, but Houston were able to pull away late on.
Eric Bledsoe led the way late on, scoring 10 of his 25 points in the fourth quarter to help the team overturn a first-half deficit and bounce back from their only defeat of the season.
The visitors had a 17-point lead heading into the fourth quarter, before an 18-point quarter from Isaiah Thomas brought the Suns back into contention, but Al Horford was able to seal the win with some late baskets.
Results in full: Miami Heat 104-95 Toronto Raptors, Utah Jazz 88-104 Brooklyn Nets, Indiana Pacers 99-91 Detroit Pistons, Charlotte Bobcats 102-97 New York Knicks, Phoenix Suns 104-98 New Orleans Pelicans, Los Angeles Lakers 104-123 Dallas Mavericks, San Antonio Spurs 102-94 Denver Nuggets, Houston Rockets 116-101 Portland Trail Blazers, Atlanta Hawks 105-100 Sacramento Kings