The 15-time All-Star, 35, who has been out with an Achilles tear since April, is set to return to the court and start for tonight's visit of the Toronto Raptors.
D'Antoni said that Bryant is "ready to go" but does not expect him to play more than 30 minutes.
"He's totally well and ready to go. I think he'll be limited by his wind and ability to be able to take the pounding," said D'Antoni.
"So, I would be surprised if more than in the twenties. It shouldn't be any more than that."
The Lakers have begun the season with a 10-9 record, while opponents Toronto are currently 6-12.