Simon Grayson's side, who secured promotion via the League One playoffs last season, began their campaign with a 1-0 defeat to Cardiff City, although the manner of their performance would have handed the club confidence that they can compete in this division.
Meanwhile, Nottingham Forest, with new owners in tandem, began their season with a 1-0 victory over Bristol City and will look to improve on their run of just four wins in 22 games against Huddersfield.
The last time the two sides met came four years ago, when they shared the points in a 1-1 draw in League One.
Meanwhile, Forest are expected to remain unchanged with Andy Reid continuing on the left side of midfield once more.
Huddersfield Town: Smithies; Dixon, Clarke, Hunt, Lynch; Norwood, Clayton, Arfield, Scannell; Novak, Rhodes
Nottingham Forest: Camp, Maloney, Halford, Collins, Harding; McGugan, Guedioura, Gillett, Reid; Majewski; Blackstock
Sports Mole says: 2-1