The club are competing for a top-four position in the Premier League, while they face two crucial cup games with Rubin Kazan and Manchester City in the space of three days next week.
The Blues have altered at least half of their starting lineup for the previous three games, and the former Liverpool boss has admitted that the trend will continue for the foreseeable future.
The 52-year-old told reporters: "We know that it will be difficult, but I have confidence that we can manage the squad.
"We can make changes between or before games so the players have fresh legs and we can carry on until the end.
"I don't know how many we will change, but we'll have to change players, that is true."
The Stamford Bridge outfit host Sunderland on Sunday.