Williams was completely outplayed by the Romanian and it is not the first time she has lost the showpiece at SW19.
Here, PA looks at her other final defeats at the All England Club.
The beginning of what became an intense – and sometimes bitter rivalry, began when a 17-year-old Maria Sharapova introduced herself to the world with a 6-1 6-4 win.
After Williams' first two titles came at the expense of her sister Venus, the older sibling got some revenge with a 7-5 6-4 victory.
In her first Wimbledon back after giving birth, a brilliant comeback story was ruined as Angelique Kerber won the title for the first time with a 6-3 6-3 triumph.