"I don't know how I managed to do it but I completely screwed up my left heel," he said. "I haven't seen the doctor yet and I don't know what he's going to say.
"Nico was playing great tennis, hitting the ball powerfully from both wings. But I was feeling great today, I wasn't feeling tired at all from my previous matches.
"It was a beautiful day for tennis and I really felt I could play well. And I could not be more pissed off with the way I finished the competition."
Tipsarevic has never progressed beyond round four of the Melbourne Grand Slam.