This is the first of two meetings between the sides, with the reverse fixture set to come up in the final month of the season, and it may prove to be a pivotal contest in the battle for survival in the Dutch top flight.
The appointment of a new manager at Willem II has made an instant impact as they defeated Emmen 2-0 on Sunday, picking up what was only their third win of the season.
Zeljko Petrovic would have been delighted with his team's performance in the game as they showed great mettle and resolve throughout the 90 minutes.
The win has taken De Superkruiken to within three points of RKC Waalwijk in 15th place, and a point above Saturday's visitors in the race to beat the drop.
Den Haag picked up a hard-fought point on Sunday, following a 1-1 draw against Sparta Rotterdam, which many people will not have seen coming.
They clearly have the historical advantage in this one, having won 12 of the last 17 games between the teams, and each of the last four away from home.
Willem II Eredivisie form: LLDLLW
ADO Den Haag Eredivisie form: WLLDLD
ADO Den Haag form (all competitions): LLLDLD
Bobby Adekanye was handed his full ADO Den Haag debut last time out when he was largely underwhelming, and he will be hopeful of a more productive outing this time.
Peet Bijen has not featured for Den Haag in over three months due to the damaged ankle he suffered in his side's KNVB-Beker meeting with Sparta Rotterdam in October.
The away team are also unable to call upon Daryl Janmaat for this one as he remains out with a knee injury, but he should be back later in the month.
Dries Saddiki is a major doubt for the hosts as he steps up his recovery from a muscle tear which he sustained three weeks ago.
Miquel Nelom's involvement has a lesser degree of uncertainty about it as he will definitely miss the game as well as the remainder of the season.
Willem II possible starting lineup:
Brondeel; Kohn, Peters, Heerkens, Owusu; Kohlert, Llonch, Spieringhs, Nunnely; Pavlidis, Okyere Wriedt
ADO Den Haag possible starting lineup:
Koopmans; Familio-Castillo, Kemper, Del Fabro, Van Ewijk; Goossens, Vejinovic, Pinas; Adekanye, Kramer, Besuijen
We say: Willem II 2-0 ADO Den Haag
Willem are looking like the more confident team at the moment, and this usually plays a major part in affairs of this nature, so we are backing them to come away with all three points.