Latics boss Roberto Martinez is no stranger to dragging Wigan out of the bottom three, and they could move into safety if they win depending on goal difference with Aston Villa.
In contrast, the Hammers could leapfrog Fulham into 10th place if manager Sam Allardyce steers his side to victory on home turf against the Latics on Saturday.
Wigan managed to come out on top with a 2-1 victory over West Ham back in October, but the Hammers will be buoyed by their 2-2 draw with Manchester United on Wednesday.
West Ham United: DDDWL
Wigan Athletic: LDWWL
Possible starting lineups
West Ham United: Jaaskelainen; Demel, Collins, Reid, O'Brien; Diame, O'Neil; Jarvis, Nolan, Vaz Te; Carroll
Wigan Athletic: Joel; Alcaraz, Scharner, Figueroa; Boyce, Gomez, McCarthy, Beausejour; McManaman, Kone, Maloney
Sports Mole says: 2-1