Watford manager Gianfranco Zola makes a quadruple change to the team who lost 1-0 at Millwall on Tuesday.
Matthew Briggs, Mark Yeates, Cristian Battocchio and Matej Vydra all drop out, while Marco Cassetti, Jonathan Hogg, Almen Abdi and Fernando Forestieri come into the side.
Blackburn Rovers caretaker boss Gary Bowyer has opted for just a single change to the team that beat Huddersfield Town 1-0 in midweek.
Midfielder David Dunn replaces the injured Jason Lowe, who has failed to recover from a kick sustained against the Terriers.
Watford: Almunia, Doyley, Ekstrand, Cassetti, Anya, Hogg, Chalobah, Abdi, Pudil, Deeney, Forestieri
Blackburn: Sandomierski, Kane, Dann, Givet, Markus Olsson, King, Jones, Williamson, Dunn, Best, Rhodes
