Richarlison, Kiko Femenia and Adrian Mariappa miss out from the XI that fell to defeat against Tottenham Hotspur, while Daryl Janmaat, Roberto Pereyra and Troy Deeney - returning from an ankle problem - come in.
For the visitors, Rafael Benitez makes two changes for what is his 300th Premier League match in the dugout.
Mikel Merino, meanwhile, takes a place on the bench having recovered from a back injury.
Watford: Karnezis; Janmaat, Cathcart, Kabasele, Holebas; Hughes, Doucoure, Capoue, Pereyra; Deeney, Gray
Subs: Gomes, Britos, Mariappa, Femenía, Deulofeu, Richarlison, Sinclair
Newcastle United: Dubravka; Manquillo, Lascelles, Lejeune, Dummett; Diame, Shelvey, Murphy, Kenedy; Perez; Gayle
Subs: Darlow, Ritchie, Hayden, Joselu, Yedlin, Merino, Haidara
Follow all the action from Vicarage Road with Sports Mole's live text commentary.