The Hornets currently sit 18th in the Championship table having gained six points from five games, while they have lost three of their last six matches at home. Meanwhile, Brighton currently sit third in the table following three straight wins.
Brighton recorded a 1-0 FA Cup win the last time the two sides met in January 2011, but they have not met in the league since 2006, when Watford recorded a 1-0 victory.
Watford boss Gianfranco Zola could have Alex Geijo available for his debut on Tuesday, although he is expected to start on the bench. Meanwhile, skipper John Eustace misses the match through injury, along with Prince Buaben.
Meanwhile, Brighton will have Craig Mackail-Smith available despite the five-goal striker picking up a groin injury in Friday's 3-0 win over Sheffield Wednesday. However, Vicente remains unavailable with an ankle knock.
Watford: Almunia; Doyley, Neuton, Nosworthy, Pudil; Yeates, Hogg, Abdi; Murray, Iwelumo, Vydra
Brighton: Kuszczak; Bruno, Greer, El-Abd, Bridge; Hammond, Bridcutt, Dicker; Buckley, Mackail-Smith, Barnes
Sports Mole says: 1-2