Wales manager Chris Coleman has handed a late call-up to Barnsley striker Tom Bradshaw for World Cup qualifiers against Georgia and the Republic of Ireland.
The prolific attacker was already a doubt due to being left out of Real Madrid's squad for Sunday's 2-0 win over Espanyol in La Liga.
A statement from the Football Association of Wales read: "Following dialogue with Real Madrid, Bale was sent for a scan and results confirmed that he wouldn't be fit to feature."
Bradshaw, who made his international debut in March last year, will join up with the rest of the Wales squad later today.
The Dragons currently sit second in Group D.