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Toulouse dominated from the off and some neat play between Ben Yedder and Martin Braithwaite almost proved enterprising, as the latter saw his stinging effort saved at the bottom corner of goal.
The hosts made their superiority count after 10 minutes when Akpa-Akpro latched on to Oscar Trejo's inventive through ball to tuck home into the bottom right corner.
The visitors were put in further discomfort just before the break when Ben Yedder produced an unstoppable free kick which flew past a helpless Anthony Lopes and into the bottom corner.
Lyon pulled one back through Lacazette in the closing 15 minutes, but it proved too little too late as Toulouse secured three early-season points.