However, Le Tefece will be looking to make it two wins from two at home in the league, and will also be keen to bounce back from their defeat at Caen.
Toulouse will no doubt be looking to avoid another fight for survival in Ligue 1 this term after narrowly avoiding the drop last season.
Les Pitchouns ended the 2014-15 campaign one place above the relegation zone, albeit five points clear of Evian TG.
However, that had followed three seasons of top-half finishes and Toulouse will hope to rediscover that form again.
If Toulouse are to finish higher in the league, they will need to snap out of their indifferent form, which was seen them win three and lose three of their last eight fixtures, stretching into the end of last season.
They will also hope to improve their recent indiscipline, after having players red-carded in both of their league games so far.
Recent form: LWLLWL
Monaco have made an indifferent start to their season, as they lie just outside the top three in the French top flight, but are facing a possible early exit from the Champions League.
Les Rouges et Blanc snuck into final qualification round for Europe's premier club competition after Marseille's slump in form saw Leonardo Jardim's men beat OM to third spot.
However, Monaco, who reached the quarter final of last year's Champions League, are in danger of elimination before the group stages after they were beaten 3-1 by Valencia on Wednesday.
AS have, at least, started their domestic campaign on the front foot after they came back to beat OCG Nice at the Allianz Riviera.
Injury to playmaker Joao Moutinho will have done little to help the Monagasque's cause, but Jardim's anger at the "unfair" nature of their defeat against Los Che could spur on the seven-time champions.
Recent form: WLWWWD
Recent form (all competitions): LWWWDL
Monaco could look to recall El Shaarawy after the ex-AC Milan forward was benched for the loss against Los Che.
However, Jardim could opt for the same frontline of Martial, Silva and Ivan Cavaleiro for the return to domestic action.
Toulouse will be without the suspended Uros Spajic for the visit of AS after his late red card in the defeat to Caen.
His place could go to central defender Maxime Spano, who was on the bench for Le Tefece last weekend.
Aleksandar Pesic is also banned following his sending-off in the victory over Saint-Etienne in the opening game.
Toulouse possible starting lineup:
Goicoechea, Biyik, Spano, Ninkov, Moubandje, Doumbia, Akpa-Akpro, Didot, Braithwaite, Ben Yedder, Trejo
Monaco possible starting lineup:
Subasic; Ragic, Carvalho, Wallace, Elderson; Fabinho, Toulalan, Pasalic; Silva, Martial, Cavaleiro
Head To Head
Monaco boast a good record against Toulouse, having lost only three of their 19 games at the Stadium Municipal.
Indeed, Les Rouges et Blancs have lost only once away to Le Tefece since January 2001, which came when a brace for Moussa Sissoko saw AS beaten in February 2011.
On the Monagasque's last visit to Midi-Pyrenees outfit, they ran 4-1 winners towards the end of last season.
We say: Toulouse 0-2 Monaco
Monaco's defeat at Valencia may convince Toulouse that their opponents' confidence could be brittle, but if Jardim's angry response is a guide, then AS may want to put on a performance to boost their chances of competing for a top-three place or better.