Toronto vs. Orlando City (Saturday, 8.00pm)
Following a controversial fourth consecutive defeat in their Major League Soccer campaign, Toronto return to BMO Field on Saturday to face a side that they have not beaten in the regular season since 2019 in Orlando City.
We say: Toronto 1-1 Orlando City
Consistency has been a significant issue for both teams throughout the campaign, with Orlando struggling to create a lot of chances while the Reds seem to be frequently collecting the ball out of their own goal.
The Lions have not lost consecutive regular-season encounters since September of last year, although Toronto have not been blanked at home in 2022, making a draw a reasonable assumption.
Colorado vs. Los Angeles (Saturday, 8.30pm)
The number one team at the moment in Major League Soccer, Los Angeles FC, can extend their unbeaten run to seven games in all competitions when they battle a side that finished the 2021 regular season as the top team in the Western Conference, the Colorado Rapids.
LA have 23 points this year after 12 fixtures, while the Burgundy Boys are one of seven teams unbeaten at home this year, having earned 11 of their 12 points so far at Dick's Sporting Goods Park.
We say: Colorado Rapids 2-3 Los Angeles FC
These two teams have built a solid foundation, and they are both collectively strong, which should be more than enough to see them each make the playoffs this season.
Ultimately, we believe that the attacking depth of LA is just a little better than the Burgundy Boys, whose new number nine, Zardes, is still trying to get his feet wet in Colorado.
Charlotte FC vs. Montreal (Sunday, 12.00am)
Having enjoyed a particularly strong start to the Major League Soccer campaign, CF Montreal will look to strengthen their position at the top end of the Eastern Conference on Saturday, when they travel to take on Charlotte FC.
With 17 points from their opening 10 games, the visitors sit third in the group, while their hosts find themselves just outside of the playoff places at this early stage of the season.
We say: Charlotte FC 1-2 CF Montreal
While Charlotte will be pleased with their return to winning ways last time out, CF Montreal have enjoyed the far stronger start, and we see their momentum carrying them to another win with top spot in their sights.
NY City vs. Columbus Crew (Sunday, 12.00am)
The visitors have gone three matches without a loss themselves, and a victory at the weekend could potentially see them climb into the playoff spots in the Major League Soccer Eastern Conference.
We say: New York City FC 3-0 Columbus Crew
Columbus Crew might be heading into this game on the back of three games without a loss, but they are heading to the Yankee Stadium, where their opponents have been dominant.
New York City are performing with great quality right now, particularly with their offensive qualities, and that should lead to them securing another victory.
Vancouver vs. Earthquakes (Sunday, 12.00am)
A 90th-minute goal gave the Caps their second victory of the year last Sunday, while San Jose have points in three of their previous four domestics fixtures.
We say: Vancouver Whitecaps 3-2 San Jose Earthquakes
The Caps may have caught a break with that disallowed goal a week ago, but that was perhaps their best performance of the season as they looked more dangerous going forward and created some effective pressing and counterattacks.
Things have looked a lot better in San Jose, but this team still seem to struggle on the road and are often caught out of position defensively, while appearing overwhelmed when marching into foreign territory.
Philadelphia vs. NY Red Bulls (Sunday, 12.30am)
It is a top-of-the-table clash between the two teams with just a point separating them in the Major League Soccer Eastern Conference, and the visitors would find themselves climbing into first place with a victory.
We say: Philadelphia Union 1-2 New York Red Bulls
This is bound to be a close game due to the fact they are the two top teams in the MLS Eastern Conference right now, which is something that should lead to a closely-fought encounter.
However, because the U have been struggling with their performances as of late, the chances are that New York Red Bulls will have enough to take all three points from this one.
Chicago Fire vs. Cincinnati (Sunday, 1.00am)
The hosts are currently second bottom of the league after winning just two games, meanwhile the visitors are undefeated in their previous three matches in the division.
We say: Chicago Fire 0-2 FC Cincinnati
Both of these teams are enjoying vastly different seasons right now, and because of that they should be heading into the match with opposing levels of confidence.
Chicago Fire could end up at the foot of the table with a defeat, and the visitors should be able to secure a routine win on Sunday.
Inter Miami vs. DC United (Sunday, 1.00am)
The hosts got back to winning ways in the U.S. Open Cup in midweek, meanwhile, the visitors ended up suffering a 3-0 loss as they head into this match.
We say: Inter Miami 1-1 DC United
Both of these teams have struggled at the start of this MLS campaign, and neither head into the game with much confidence in terms of picking up victories.
Because of that, it would not be a surprise to see them battle it out to a draw, even though sharing the points does not help either of them in terms of the league.
Houston vs. Nashville (Sunday, 1.30am)
Meanwhile, the away side come into the clash looking to pick up a third consecutive victory across all competitions.
We say: Houston Dynamo 1-1 Nashville SC
There is little to choose between the sides coming into this one which promises to be an exciting watch. We fancy the teams to match each other stride for stride over the course of the 90 minutes, giving rise to a share of the spoils.
Salt Lake vs. Austin (Sunday, 2.30am)
The teams are separated by just three places and four points in the league table, and this weekend's clash has all the makings of an enthralling affair.
We say: Real Salt Lake 1-0 Austin FC
Real Salt Lake's near-perfect home record this term means that it is hard to envisage any other outcome than a home win, and while we expect the visitors to put up a good fight, we are backing the hosts to emerge victorious.
Portland vs. Kansas (Sunday, 3.00am)
On the other hand, the away side come into this one looking to make it back to back victories for the first time this term having ended a run of six straight winless matches last time out.
We say: Portland Timbers 1-0 Sporting Kansas City
Both sides have struggled in front of goal this term, so we expect a low-scoring affair with little goalmouth action. That said, we are also backing the home team to narrowly edge out their visitors and come away with all three points.
LA Galaxy vs. Dallas (Sunday, 3.30am)
On the other hand, Dallas will be looking to get back to winning ways straight away having suffered a first defeat in 10 matches last time out.
We say: Los Angeles Galaxy 2-1 Dallas
With just goal difference separating the sides in the league table, we anticipate an open and end-to-end affair with chances at both ends. Having said that, we are also tipping the home side to carry the day, albeit by only a narrow margin.