Both sides are through to the fourth round of the League Cup following their respective victories. However, Wigan are determined not to record a third consecutive defeat in the league following their 2-1 loss to Fulham last weekend.
O'Neill will be without captain Lee Cattermole after the midfielder was sent off for the seventh time in his career during the Black Cats' 2-0 win over MK Dons in the League Cup this week, which means that David Vaughan could be placed in the starting XI.
Sunderland: Mignolet; Gardner, O'Shea, Bramble, Rose; Larsson, Colback, Vaughan, McClean; Sessegnon; Fletcher
Wigan: Al Habsi; Boyce, Caldwell, Ramis, Figueroa; Beausejour, McCarthy, Watson, Gomez; Maloney; Kone
Sports Mole says: 2-1