The Millers got their second win of the season against Sheffield Wednesday in midweek, while the Potters lost to Swansea.
Paul Warne admitted that it was a relief to finally pick up a victory, with his side having not won since the opening day prior to Wednesday night.
It was reward for some promising performances so far this season, and the Millers look far better equipped to deal with life in the Championship than they have done in previous campaigns that have ended in relegation.
Warne will now be targeting a rare three points on the road – Rotherham have only two wins in their last 52 away games in the second tier.
If history is anything to go by, they might be in with a shot as Stoke have won just one of the last 10 league meetings between the two sides.
The Potters were comfortably outplayed in a 2-0 defeat to Swansea on Tuesday, registering just three shots, none of which was on target.
It was their first loss in six games and Michael O'Neill was left frustrated by the performance and the result, particularly as a win would have taken his team into the playoff positions.
Stoke's promotion credentials will be tested again with upcoming fixtures against Watford and Reading, so O'Neill may feel that victory on Saturday is vital to give them a springboard going into those games.
However, the Potters have won just once at home in the league this season and are yet to keep a clean sheet at the bet365 Stadium in four games.
Stoke City Championship form: WDWDWL
Stoke City form (all competitions): WDWDWL
Rotherham United Championship form: DDLDLW
Michael O'Neill has admitted that the gruelling demands of the Championship fixture schedule are forcing him to make changes every game to keep players fit.
Paul Warne will hope he has struck upon a winning formula so could name the same team that started the win over Sheffield Wednesday.
Jamal Blackman continues to start in goal despite a problem with his ankle, but the Chelsea loanee is in excellent form so would be hugely missed if taken out of the side.
Stoke City possible starting lineup:
Gunn; Smith, Chester, Souttar, Fox, McClean; Mikel, Thompson, Powell; Fletcher, Campbell
Rotherham United possible starting lineup:
Blackman; Harding, Ihiekwe, Wood, Mattock; Lindsay, Wiles, Barlaser; Jozefzoon, Ladapo, Miller
We say: Stoke City 0-0 Rotherham United
Buoyed by victory in midweek, Rotherham will travel to Staffordshire full of confidence and they could take a point against a Stoke side who cannot afford to put in another performance like they did against Swansea.