The Potters are just one point clear of the drop while Millwall are a point off the playoffs, and a win for either would be a major boost.
Stoke's recent form has been patchy, winning three of their last six league games, but the points they have picked up have proved enough to lift them out of the relegation zone after a disastrous start to the campaign.
The Potters did not win in their first 10 Championship games, losing eight of those fixtures as they sank towards the bottom of the table.
The reverse fixture between these two in late October ended in a 2-0 win for Millwall in London, and Stoke will be hopeful of preventing their opponents from recording a league double over them.
Millwall, on the other hand, are in fine form as they mount an unexpected playoff charge after an unremarkable start to the season.
The club have lost just once in their last 12 games across all competitions - a surprising 2-1 home defeat to Barnsley, mired in the relegation zone.
Their strong form sees the club seventh in the table and just three points behind third-placed Brentford, meaning that a win could well lift them into the top six.
Stoke City Championship form: WDLWLW
Stoke City form (all competitions): DLWLWL
Millwall Championship form: WWLDWW
Millwall form (all competitions): WLDWWW
Stoke head coach O'Neill is blessed with an almost fully-fit squad to choose from.
Only Ryan Shawcross - a long-term absentee - is missing for the Potters, meaning that O'Neill has plenty of options available.
However, he has an otherwise fully-fit squad outside of those four.
Stoke City possible starting lineup:
Butland; Smith, Batth, Lindsay, Martins Indi; Allen, Powell, Clucas; Campbell, Vokes, McClean
Millwall possible starting lineup:
Bialkowski; Hutchinson, Pearce, Cooper; Romeo, Molumby, Williams, Ferguson; Wallace, Smith, O'Brien
We say: Stoke City 0-0 Millwall
Both sides are in decent form and, while Millwall are the better side at present, Stoke have plenty riding on this fixture as well. Coupled with home advantage, the hosts may battle to just their fourth league draw of the season.