The hosts, meanwhile, will attempt to clinch their first points of the season after falling to a 2-0 defeat to Millwall on the opening weekend of the season.
Since being relegated from the Premier League four years ago, Stoke have finished no higher than 14th place in the Championship.
In fact, they ended their last two campaigns in 14th position, but they will be aiming to push into the top half of the table this term.
However, to achieve a top-12 finish, Stoke will need to avoid too many performances like the one that they offered up in their season opener against Millwall.
Poor defending from set-pieces ultimately cost the Potters, who conceded two Charlie Cresswell goals from corner kicks which condemned them to a 2-0 away defeat.
As they turn their attention to their first home game of the season, Stoke will look to draw inspiration from the end of last season when they lost just one of their final five home matches.
While Stoke were unable to achieve a positive result last weekend, Blackpool got off to a winning start under new manager Michael Appleton.
Appleton began his tenure with a home encounter against Reading, and it proved to be a successful outing, with a ninth-minute Callum Connolly strike guiding Blackpool to a 1-0 victory.
After winning his opening match in his second spell as Blackpool boss, Appleton will now set about achieving a successful away result on Saturday.
The Tangerines only managed to win five away league games last season, and an improvement in their away form this season could see them operate in the top half of the table.
Ben Wilmot was forced off late on against Millwall with a groin problem, and as a result, the defender is a doubt for Saturday's contest.
Last season's top scorer Jacob Brown was used as a second-half substitute last weekend, but the 24-year-old is expected to come into the lineup for Stoke's first home game of the season.
Stoke City possible starting lineup:
Bursik; Taylor, Jagielka, Flint; Clarke, Laurent, Clucas, Baker, Tymon; Campbell, Brown
Blackpool possible starting lineup:
Grimshaw; Connolly, Ekpiteta, Keogh, Thompson; Virtue, Fiorini, Carey; Bowler, Yates, Madine
We say: Stoke City 1-1 Blackpool
No side drew more away games in the Championship than Blackpool last season, and we think that they will continue that trend in their first away match of the season by playing out a draw with Stoke.
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