While the home side finished seven places above their upcoming opponents during the last campaign, the visitors are being tipped to mount a promotion bid this time around.
Missing out on a playoff spot by two points would have hurt Millwall boss Gary Rowett, especially with just four wins being recorded from nine matches after the resumption.
However, ahead of the meeting with his former club, Rowett will feel that all of the foundations have been laid ahead of an improved campaign.
Changes in personnel have been kept to a minimum, with Scott Malone and Troy Parrott joining players in Ryan Woods and Mason Bennett who made impacts while on loan at the Lions during the first seven months of 2020.
With Millwall the lowest scorers of the top 15 last season, the addition of Tottenham Hotspur loanee Parrott could prove pivotal as the 18-year-old looks to impress Jose Mourinho.
While Rowett has favoured stability ahead of the new season, opposite number Michael O'Neill has gone for the opposite, shaking up a Stoke side which have under-performed since their relegation from the Premier League.
The former Northern Ireland boss has opted for a blend of youth and experience, but winning the race to bring in forward Steven Fletcher on a free transfer could prove to be one of the signings of the season at this level.
Fellow 33-year-old John Obi Mikel is also back in England after a spell with Trabzonspor, and the hugely-successful Nigerian could give the dressing room an extra edge.
Although Stoke only ended the most recent campaign in 15th position, they recorded four wins and a draw from their closing six matches, a run which included taking the scalp of Brentford.
Millwall form (all competitions): W
Stoke City form (all competitions): W
Millwall be without Ryan Woods, who is unable to play against his parent club at the weekend.
Despite his return from international duty, Jon Dadi Bodvarsson could be kept among the replacements for this fixture.
Two weeks have passed since Stoke's EFL Cup tie against Blackpool, meaning that O'Neill may now have different thoughts about the make-up of his team.
Millwall possible starting lineup:
Bialkowski; Hutchinson, Wallace, Cooper; Leonard, Thompson, Williams, Malone; Mahoney, Smith, Bennett
Stoke City possible starting lineup:
Davies; Smith, Chester, Batth, Martins Indi; Powell, Clucas, Mikel, McClean; Campbell, Fletcher
We say: Millwall 1-1 Stoke City
Neat passing games are unlikely to be on show in East London as both teams look to impose their physicality on proceedings. With that in mind, we can only predict a hard-fought draw between two sides who will not be prepared to give an inch.