The Saints shared the points with Dundee United last time out, while the Buddies came from behind to secure a point at home to Motherwell.
St Johnstone were unable to secure their first win since early November as they could only draw away at Dundee United on Tuesday evening.
St Johnstone have struggled at home this season, scoring just four goals in their 11 home league games, fewer than any other Scottish Premiership club on home soil in 2020-21.
The Saints, however, do have a good home record against St Mirren, having won seven of their last nine league matches against them at McDiarmid Park, keeping a clean sheet in each of their last five fixtures.
Victory on Saturday would be their fifth top-flight win of the season and could move them level on points with St Mirren, who sit one place above them in eighth.
Manager Jim Goodwin has been impressed with his side's performances over the last few months, which has seen the Buddies lose just two of their last 16 matches in all competitions.
St Mirren head into their clash against St Johnstone having lost only one of their last six league meetings against them – a 1-0 loss in August earlier this season – but they did record a 3-2 victory in their last meeting in December.
Securing the three points this weekend could see the Buddies climb up to seventh in the Scottish Premiership, eight points clear of the relegation zone.
St Johnstone Scottish Premiership form: LLLDDD
St Mirren Scottish Premiership form: WLWLDD
St Johnstone manager Davidson has no injury or suspension concerns heading into this weekend's match.
Like Davidson, St Mirren boss Goodwin has no injury or suspension concerns for Saturday's fixture.
Striker Eamonn Brophy, who made his debut as a second half substitute against Motherwell, impressed when he came off the bench and could be handed his first start for the club this weekend.
New signing Collin Quaner, who joined the club on a free transfer from Huddersfield Town last Friday, could also feature up front on Saturday.
St Johnstone possible starting lineup:
Clark; Rooney, Gordon, McCart; Brown, McCann, Davidson, Booth; Melamed, Wotherspoon; May
St Mirren possible starting lineup:
Alnwick; Fraser, McCarthy, Shaughnessy, Tait; Connolly, McGrath, Doyle-Hayes, Erhahon, Durmus; Brophy
We say: St Johnstone 1-2 St Mirren
St Johnstone have picked up just nine points at home this season, while St Mirren have lost only one of their last five away league outings. Goodwin's side will be hoping to take advantage against the hosts, who are enduring a poor run of form, and we can see them securing all three points away at McDiarmid Park.