Jose Mourinho's men are desperate to avoid a fifth game without a win in the top flight following two draws and two losses since beating Arsenal earlier in December, and Wolverhampton Wanderers took a deserved point from their clash with Spurs last weekend.
Tottenham currently find themselves in seventh before Saturday's visit of Leeds, although they do have a game in hand over some of the top six after Wednesday's clash with Fulham was postponed due to a coronavirus outbreak at Craven Cottage.
Here, Sports Mole looks at how Spurs could line up for this weekend's contest with Marcelo Bielsa's side.
Mourinho opted for a three-man defence against Wolves, but that move did not pay dividends at Molineux and he is expected to revert to his tried-and-tested 4-2-3-1 here.
Matt Doherty was handed a start against his former club but is likely to cede his place to the returning Serge Aurier here, while Toby Alderweireld should reprise his regular role alongside Eric Dier in the heart of defence.
Harry Winks enjoyed a rare outing from the first whistle against Wolves, but with Moussa Sissoko fit and raring to go again, the Frenchman is expected to pair up with the ever-present Pierre-Emile Hojbjerg in the Spurs midfield.
The hosts could be without as many as three attackers for the visit of Leeds, with Gareth Bale definitely out while Brazilian duo Lucas Moura and Carlos Vinicius are touch-and-go with unspecified issues.
The absences of Bale and Lucas all but guarantees a start on the right-hand side for Steven Bergwijn, and with Giovani Lo Celso also sidelined for the next couple of weeks, Tanguy Ndombele and Dele Alli will battle it out to start in the number 10 role.
Ndombele could get the nod over the out-of-favour Alli after taking just 57 seconds to open the scoring at Molineux, while Harry Kane and Son Heung-min will be looking to rediscover their goalscoring touch against a depleted Leeds defence this weekend.
Watch the Sports Mole Football Shorts prediction for this game below: