Tottenham Hotspur will welcome back as many as four players as they attempt to record their first victory in five games.
Tim Sherwood's side were missing at least half-a-dozen first-team players for their trip to Benfica on Thursday evening, but Younes Kaboul, Jan Vertonghen, Mousa Dembele and Emmanuel Adebayor will return for the visit of Southampton.
However, captain Michael Dawson is likely to remain on the sidelines with a hamstring injury.
Southampton boss Mauricio Pochettino has witnessed his team record back-to-back league victories for the first time since October.
Wins over Crystal Palace and Norwich City respectively have taken the Saints closer to overhauling Manchester United in the standings.
Tottenham Hotspur: WWLLLD
Possible starting lineups
Tottenham Hotspur: Lloris; Naughton, Rose, Kaboul, Vertonghen; Sandro, Townsend, Dembele, Chadli, Eriksen; Adebayor
Southampton: Boruc; Clyne, Shaw, Fonte, Lovren; Schneiderlin, Ward-Prowse, Davis, Ramirez, Lallana; Rodriguez
Sports Mole says: 1-1