Spurs have won just once in five attempts over the summer, but their lone victory was a resounding 6-0 thumping of South China.
New signing Roberto Soldado is expected to spearhead the attack for the North London club, while defender Jan Vertonghen could be given a run-out to gain match fitness following a spell on the sidelines.
Gareth Bale is unlikely to feature while his Spurs future lies in the balance.
The match will also serve as Espanyol's final warm-up for the new season following last weekend's draw with Montpellier. Their league campaign gets underway at Celtic Vigo on August 18.
Possible starting lineups
Spurs: Lloris; Walker, Fryers, Livermore, Vertonghen; Dembele, Parker; Lennon, Chadli, Soldado; Defoe
Espanyol: Kiko Casilla, Mattioni, Abraham, Sergio G, Lanza, H. Moreno, David López, Capdevila, Colotto, Wakaso, Pizzi
Sports Mole says: 2-1