Ten-man Spurs were hammered 5-1 by the Citizens at White Hart Lane on Wednesday - their first top-flight loss under Tim Sherwood - two months after they were thrashed 6-0 at Eastlands. However, the Lillywhites have fared better against Hull this term.
They edged past Steve Bruce's men 1-0 in the Premier League courtesy of a Roberto Soldado penalty, while spot kicks were needed for them to eventually beat the Tigers in the Capital One Cup fourth round.
The Spaniard, benched for the last two games, could be recalled to Sherwood's starting XI this weekend if the Tottenham manager opts to revert to 4-4-2 and partner him with Emmanuel Adebayor.
Moussa Dembele limped off at half time in midweek and therefore Etienne Capoue could be handed a first start since New Year's Day, if neither Paulinho nor Sandro are fit to compete for midfield places.
Hull have lost five Premier League matches in a row to slip from the comfort of the top half of the table to within four points of the relegation zone, with the latest defeat coming at Crystal Palace on Tuesday.
It has also been four games since the Tigers found the net in top-flight competition and so Bruce will be looking to newly-recruited strike force Shane Long and Nikica Jelavic to get them firing again.
Neither have yet to open their accounts for the Lancashire outfit, but are likely to be partnered together on Saturday, with Sone Aluko still sidelined. Defender James Chester is another long-term absentee and goalkeeper Allan McGregor is banned, so Steve Harper will take his place between the sticks.
Possible starting lineups
Hull: Harper; Elmohamady, Bruce, Davies, McShane, Figueroa; Huddlestone, Meyler, Koren; Long, Jelavic
Spurs: Lloris; Walker, Dawson, Chiriches, Rose; Eriksen, Bentaleb, Capoue, Lennon; Adebayor, Soldado
Sports Mole says: 1-1