Despite admitting that the hosts are unlikely to adopt a radical new style, Villas-Boas is aware that they may be boosted by their new boss.
"The reality is that with a change of manager the Fulham side won't be completely different, but I'm sure we'll see some new things," he told the club's official website.
"The motivation of a new coach is also important, especially for fringe players who weren't involved before. It gives them a lift and a new start.
"Fulham's system could be a surprise. We can't predict what is going through Rene's mind so we have to be careful."
Spurs head into the match without a win in their last four league games.