Harry Kane has suffered a lateral ligament injury to his left ankle which could threaten to end the Tottenham striker's season prematurely.
Here, Press Association Sport looks at the extent of those injuries and how Spurs coped without him.
September – November 2016
Kane first sustained an ankle injury in a 1-0 Premier League win over Sunderland in September 2016 – where he scored the winner. He fell awkwardly in the final few minutes and scans revealed ligament damage. He ended up missing 10 Tottenham games in total, also missing an international break and returned for a 1-1 draw at Arsenal on November 6. Spurs had a mixed time without him, winning the first four games of his absence, including a 2-0 success over Manchester City, but then things went south as they lost two and drew four of the next six – a run of games which saw them knocked out of the EFL Cup and suffer damaging results in their Champions League group campaign.
March – April 2017
The England striker suffered a repeat problem in the early stages of the 6-0 FA Cup win at Millwall in March 2017. He tangled with Jake Cooper after getting a shot away and was unable to continue. Fears were that he would be out for a similar period to his absence earlier in the same season but he only missed three Spurs games, all of which resulted in wins. He returned as a substitute against Watford in early April.
March – April 2018
Almost one year on from his last problem, Kane went down again and it was a worrying time for both Tottenham and England fans ahead of the World Cup. It looked serious as the striker had to limp off against Bournemouth after being caught trying to turn the ball into the net. However, it was a quickfire recovery from Kane, who only missed one Tottenham game, along with two England matches as he returned for the away win at Chelsea. Spurs won their only game without him, an FA Cup success at Swansea.
Another ankle problem for the England captain. He went down at the end of the 1-0 defeat by Manchester United and did not return to action until they played at Burnley nearly six weeks later – returning with a goal. Spurs won five of their seven matches without their talisman, including a 3-0 Champions League win over Borussia Dortmund.