Cristal vs. Rentistas (Wednesday, 11.00pm)
The home side cannot qualify out of Group E, however the team that finishes third in the group stage goes into the Copa Sudamericana, with Rentistas currently the team in that third spot.
We say: Sporting Cristal 0-1 Rentistas
Rentistas can ensure a place in the Copa Sudamericana at least with a victory over Sporting Cristal on Wednesday, and three points will keep slim hopes alive of progressing through the group stages in the Copa Libertadores.
Cristal's campaign in this tournament is all but over and Rentistas should use this to their advantage to capitalise on a defeated Cristal side.
Velez Sarsfield vs. Union La Calera (Wednesday, 11.00pm)
Union La Calera are yet to register a win in this tournament, while their hosts currently sit second in Group G, two points clear of third-placed LDU de Quito.
We say: Velez Sarsfield 2-0 Union La Calera
Knowing that a win for Velez Sarsfield could book their place in the next round of the Copa Libertadores with one group game to spare, depending on the result of the other game in gameweek five, should give the home side added motivation to defeat Union La Calera once more in this tournament.
Sarsfield have scored at least two goals in all but one of their group games this season and La Calera have conceded at least two goals in all four of their group games, meaning that it is likely Sarsfield will score two goals in this game.
River Plate vs. Santa Fe (Thursday, 1.00am)
Santa Fe need three points to ensure their Copa Libertadores campaign is not over, whereas the home side could confirm their progression from Group D with a win if the other game between Fluminense and Atletico Junior goes their way too.
We say: River Plate 1-1 Santa Fe
Despite a weakened River Plate side eventually losing on penalties against Boca Juniors, in 90 minutes the team managed a 1-1 draw with their greatest rivals, which will give Gallardo's side confidence heading into this game with Santa Fe.
The away side will be hoping that they can capitalise on so many absentees for their hosts but they are yet to register a win in this season's Copa Libertadores and that could well carry on this week.
Flamengo vs. LDU Quito (Thursday, 1.00am)
With two games left, the Brazilian side can secure top spot with a win, while the away team are two points behind second-placed Velez Sarsfield and could need a win this week to take it to the final game.
We say: Flamengo 3-1 LDU Quito
This fixture between the two sides produced five goals two weeks ago and is likely again to be a high-scoring affair with both teams being attack-minded.
Flamengo have been in great form of late and look to be a team to beat in this tournament while LDU have suffered four defeats in a row in all competitions.
Cerro Porteno vs. Atletico Mineiro (Thursday, 1.00am)
The away side are top of the group and have already secured a place in the last 16 of the tournament; however if the home side wins this week, they too will book their place in the knockouts.
We say: Cerro Porteno 0-2 Atletico Mineiro
It is difficult to look past the Brazilian side after their dominant performance when these two sides met a few weeks ago.
Cerro Porteno are second in the group thanks to their ability to shut out the other two teams but will certainly need to improve in attack if they want to get anything out of this game.
Tachira vs. Always Ready (Thursday, 3.00am)
Group B is all to play for with two games to go in the Copa Libertadores, with all four teams level on six points each.
We say: Deportivo Tachira 2-1 Always Ready
Juan Tolisano's side have been in fine form at home in this competition and will look to make it three wins out of three this Wednesday.
The injury to Cummings for Always Ready could prove pivotal for Omar Asad's team, who had successfully kept the opposition out last time they played.
America vs. Deportivo (Thursday, 3.00am)
It is a must-win clash in the Copa Libertadores on Wednesday night as America de Cali host Deportivo La Guaira in the penultimate game in Group H at the Estadio Olimpico Pascual Guerrero Cali in Colombia.
The hosts currently have only one point out of the possible 12 so far, meaning they have to win both their last two games to even stand a chance of progressing, while the visitors are also reliant on other results as they sit on three points.
We say: America de Cali 0-1 Deportivo La Guaira
Both sides have had a poor record in the Copa Libertadores, with the hosts failing to win in their last eight matches in this competition and the visitors in their last seven.
However, they both need to win this game to stand a chance going into the final match. The game is bound to be a low-scoring affair with Deportivo La Guaira the more likely of the two to win the game.