A win, with a clean sheet and plenty of goals, will be the order of the day for Spain, who have been victorious in each of their last nine European championship qualification fixtures.
Tuesday night will be the eighth international meeting between the two teams. Spain have won each of the previous seven, including a 4-0 victory when they last locked horns in February 1997.
Enrique is expected to make changes from the team that started against Norway, and with that in mind, Sports Mole has taken a look at how the visitors could line up on Tuesday night.
There is every chance that Enrique could decide to completely shuffle his pack, as the former Barcelona manager will feel confident that any XI he puts on the field will beat Malta.
Jaime Mata, however, came off the bench against the Norwegians for his international debut and the 30-year-old, who has scored 13 times in 25 La Liga games for Getafe this season, is another option.