The 24-year-old returns to contention having served a three-match ban but does not make a starting XI that shows two changes from the FA Cup semi-final defeat to Chelsea last Sunday.
The visiting Cherries also make two changes from their last fixture, a 2-0 league loss to Manchester United a week-and-a-half ago.
Southampton: McCarthy; Soares, Yoshida, Hoedt, Bertrand; Romeu, Lemina, Bednarek, Tadic; Austin, Redmond
Subs: Forster, Stephens, Long, Ward-Prowse, Gabbiadini, Hojbjerg, Sims
Bournemouth: Begovic; Francis, Cook, Ake, Daniels; Gosling, Cook, Fraser, Mousset; King, Wilson
Subs: Boruc, Surman, Pugh, Smith, Defoe, Mings, Ibe