Fraser Forster starts in goal, while Ryan Bertrand lines up at left-back. Graziano Pelle will lead the Saints line, with Dusan Tadic taking up in an attacking midfield role as the home side have stuck with the same team that began their 2-1 defeat to Liverpool at Anfield last Sunday.
Similarly, the visitors have named an unchanged team from last week, when they drew 2-2 at home with Sunderland.
The club's £10m record signing, Brown Ideye, will begin the match on the bench.
Southampton: Forster; Clyne, Fonte, Yoshida, Bertrand; Wanyama, Schneiderlin; Ward-Prowse, S. Davis, Tadic; Pelle
West Bromwich Albion: Foster; Wisdom, Dawson, Olsson, Pocognoli; Mulumbu, Gardner, Berahino, Dorrans, Brunt; Anichebe
You can follow Sports Mole's live text commentary of today's game between Southampton and West Brom here.