The Saints have been in tremendous form in recent weeks, picking up 12 points from a possible 18, to almost certainly secure their top-flight status next season.
West Brom have seen their pursuit of a European place next season stutter since the turn of the year, but they will be hopeful of securing just their second victory in seven games at St Mary's Stadium.
Boss Steve Clarke witnessed the Baggies come from a goal behind to draw with Newcastle United last weekend, and after making an impact from the bench, striker Shane Long could partner Romelu Lukaku in attack.
West Bromwich Albion: LWDLLD
Possible starting lineups
Southampton: Boruc; Clyne, Yoshida, Hooiveld, Fox; Schneiderlin, S.Davis, Cork, Lallana; Lambert, Rodriguez
West Bromwich Albion: Foster; Olsson, Popov, McAuley, Jones; Yacob, Morrison, Brunt, Dorrans; Lukaku, Long
Sports Mole says: 2-1