Pochettino has been heavily linked with taking over at Tottenham Hotspur following Tim Sherwood's sacking at White Hart Lane earlier this month.
However, Ward-Prowse is hoping that the Argentine decides to stay with the Saints to guide them through the 2014-15 campaign.
"It would be a major blow to lose him - all the players love him," he is quoted as saying by Sky Sports News.
"He demands a lot from us, and it is hard work, but it has been proved to work. None of us want to see him go. He is a fantastic manager and he has done really well."
Southampton secured an eighth-placed finish in the Premier League table last season under Pochettino.