Both managers headed into this FA Cup fourth-round replay claiming that their priority was league football, and that has been reflected in the numbers of changes to the starting lineups.
Hosts Southampton are without Billy Sharp, who is cup-tied, while Rickie Lambert has been made to settle for a place on the bench.
Millwall have recalled former Southampton winger Danny N'Guessan to the side. Meanwhile, Tottenham Hotspur loanee Harry Kane will play as a lone striker at St Mary's.
Southampton: Bialkowski; Richardson, Martin, Fonte, Harding; De Ridder, Chaplow, Hammond, Lallana; Do Prado, Lee
Millwall: Forde; Dunne, Ward, Barron, Craig; Mason, Wright, Trotter, N'Guessan, Henry; Kane
