To undertake that task, head coach Stefan Tarkovic should have an almost fully fit squad to select from, including veteran skipper Marek Hamsik - set to earn his 128th international cap - and impressive Inter centre-back Milan Skriniar, who kept Robert Lewandowski quiet last time out before firing in the winning goal.
Only defender Denis Vavro - as well as one staff member - is definitely ruled out, as he tested positive for COVID-19 earlier this week and must therefore self-isolate to avoid spreading infection.
The Falcons return to St Petersburg's Krestovsky Stadium as Group E leaders, so will be under no significant pressure to take the game to the Swedes, and may therefore retain a 'false nine' to add flexibility and depth to midfield.
In the absence of a conventional centre-forward, then, former Norwich City forward Ondrej Duda will most probably start as the man closest to goal, as Slavia Prague forward Ivan Schranz - a starter in the pre-tournament friendlies - could be set to be miss out again after struggling to recover from a thigh injury sustained earlier this month.
Meanwhile, on the bench, young Feyenoord frontman Robert Bozenik may be introduced later on if goals are required, while 19-year-old midfielder Tomas Suslov - also based in the Eredivisie, with Groningen - will hope for another chance to impress.
Midfielders Laszlo Benes, of Borussia Monchengladbach, and Stanislav Lobotka - rarely used by Napoli last term - remained on the sidelines on Monday, but could contend for minutes in this second outing of an intensely-paced tournament.
Slovakia possible starting lineup: Dubravka; Pekarik, Satka, Skriniar, Hubocan; Kucka, Benes; Haraslin, Hamsik, Mak; Duda