The Owls have only kept one clean sheet during the campaign, but they have avoided defeat in their last four fixtures by securing draws, with their latest coming in the form of a 1-1 draw with Barnsley.
For Reading, they have only suffered one defeat in their last six encounters, while their record on the road consists of two draws, two losses and two victories.
Nigel Adkins's men currently sit fifth in the Championship standings, but even if they snatch three away points, they will be unable to overtake third-placed Queens Park Rangers.
Sheffield Wednesday: LLDDDD
Possible starting lineups
Sheffield Wednesday: Kirkland; Buxton, Johnson, Zayatte, Johnson; Antonio, McPhail, Olofinjana, Helan; Fryatt, Nuhiu
Reading: Federici; Gunter, Morrison, Pearce, Bridge; Guthrie, Baird, Obita; McCleary, Pogrebnyak, Le Fondre
Sports Mole says: 0-1