The Yorkshire giants sit five points adrift of safety, while the Potters have dropped down to eighth spot after Tuesday's 3-2 defeat to leaders Norwich City.
When Tony Pulis was named as the replacement for Garry Monk, Sheffield Wednesday supporters would not have expected a sudden increase in goals given their previous efforts this season.
However, while their only goal during their opening two matches under Pulis has come from a set piece, claiming a share of the spoils at Swansea City will be regarded as an excellent result.
Although Pulis will insist that he is fully focused on welcoming one of his former clubs to Yorkshire, he will also have one eye on Coventry City's improvement in recent games.
The Sky Blues have opened up a five-point gap in 21st place, and it may suggest to Pulis that draws are now no longer good enough if they wish to get themselves out of the bottom three before Christmas.
Unlike their hosts, Stoke have found goals easy to come by in recent weeks with 11 strikes being recorded during their last four fixtures.
Losing first-choice goalkeepers Adam Davies and Angus Gunn to injury has not helped the cause, but the club's experienced defenders have not eased the burden on England Under-21 international Josef Bursik.
Niki Maenpaa, the former Bristol City stopper, has been brought into the squad, but there is a responsibility on each member of the squad to return to working collectively as a defensive unit.
Despite conceding six goals in back-to-back home fixtures against Huddersfield Town and Norwich City, Stoke still sit just two points adrift of the playoffs.
Sheffield Wednesday Championship form: LLWDLD
Stoke City Championship form: LWLWWL
Kadeem Harris is also in contention for an appearance after serving a three-match suspension.
Maenpaa should come in for his Stoke debut providing that he has proven his fitness in training.
Sheffield Wednesday possible starting lineup:
Wildsmith; Palmer, Lees, Borner, Aken, Odubajo; Paterson, Bannan, Luongo, Reach; Kachunga
Stoke City possible starting lineup:
Maenpaa; Souttar, Chester, Fox; Smith, Mikel, Clucas, Tymon; Powell, Fletcher, Campbell
We say: Sheffield Wednesday 1-1 Stoke City
With Stoke having struggled in defence in recent matches, O'Neill will surely look to tighten things up at the back. At a time when Wednesday are struggling for goals, that could lead to a low-scoring draw being played out at the weekend.